Michael Cosgrove, assistant professor of biology in Syracuse University's
College of Arts and
Sciences, has received a $720,000 Research Scholar Grant from the American Cancer Society.
The grant will enable Cosgrove to further his work in leukemia research.
Cosgrove studies the biochemical structure of proteins in cells. His leukemia research focuses
on one of the proteins that regulates the way DNA is packaged when white blood cells are
formed. The protein is called the Mixed Lineage Leukemia (MLL) protein. In normal cells, the
MLL protein, which contains 3,969 amino acids, combines with three other proteins to create a
molecular switch that controls the DNA packaging events required for the formation of white
blood cells. In some types of leukemia, the MLL switch is broken, which prevents white blood
cells from maturing properly. The result is a dangerous proliferation of immature white blood
cells, which can lead to leukemia.
"It is believed that leukemia develops when this switch works too fast or too slow," Cosgrove
says. "The goal of our research is to understand how this MLL switch works and to use the
information to find new medicines that will fix broken switches that cause normal cells to
transform into leukemia cells."
Cosgrove earned a Ph.D. at Syracuse University and was a postdoctoral researcher at the
Johns Hopkins School of Medicine and Cornell University. His research has also received
funding from the Leukemia Research Foundation, the Basil O'Conner Award from the March
of Dimes Foundation and a start-up grant from SU's College of Arts and Sciences. Further
information about his research is available on the Web at
http://biology.syr.edu/cosgrove/index.html.
